Niclosamide’s pharmacological actions have been shown, suggesting its potential for a wide range of applications. The drug’s capacity to untangle mitochondrial phosphorylation is generally the source of its subsequent effects. Some signaling pathways may also be controlled by it. There is a broad range of diseases and infections that the medicine may be able to effectively treat, according to the repurposing study. In addition, it may be effective against some carcinomas.
Diabetes
Diabetic prevalence in the United States is estimated at 10%. Approximately 34.2 million individuals are afflicted by this condition. Prediabetes is a major issue for 88 million Americans, or 1 in 3. Given the prevalence of metabolic disorders, it stands to reason that there are several therapeutic options that might be effective.
The niclosamide salt, Niclosamide ethanolamine, which is more soluble in water, was similarly shown to improve diabetes Miletus type 2 symptoms in mice. Mice that had been given a high-fat diet responded to this therapy with increased energy expenditure, improved metabolism, and lipid oxidation. Niclosamide ethanolamine is well recognized for its ability to lessen the spread of diseases and for its efficacy in managing high blood sugar (hyperglycemia) and glycemic control.
Disease of the Parkinson’s Type (PD)
The PINK 1 threonine-protein/mitochondrial serin kinase may be activated prematurely if its catalytic activities are altered in any way. The small chemicals which help initiate the metabolic processes in this protein are renowned for their neuroprotective qualities. This suggests that they may possibly be useful for treating this condition.
Niclosamide’s potential to help manage this illness is high due to its role as a potent activator of PINK 1 in cells. However, more PD models are required to see whether the medication can effectively treat this problem.
Infection by Viruses
Anyone may get infected with a virus if they breathe in or ingest one. The virus may also spread between humans via bug bites and sexual interaction. The upper respiratory tract, including the nose, throat, and airways, is vulnerable to viral infection. This also encompasses the digestive, neurological, and reproductive systems. Use of antiviral medicines may slow viral replication without damaging the immune system’s function. Niclosamide has shown promise as a potential pan-antiviral treatment. It may specifically target certain host pathways. This response is associated with the product’s capacity to cure the disease. Even now, researchers are exploring the possibility of using Niclosam Niclosamide as a treatment for the Zika, Ebola, and Covid-19 viruses.
Diseases Caused by Bacterial Infections
Whenever bacteria enters the human system, it rapidly multiplies and causes disease. A greater number of responses with a “trigger” potential may result. Infections caused by bacteria may enter the human body via the respiratory tract or an injury. Several bacterial illnesses may benefit from the usage of niclosamide, which is available for purchase. Primarily, it is used for the treatment of TB and methicillin-resistant Staphylococcus aureus. These findings suggest that the product is as effective as vancomycin, the standard treatment for MRSA right now.
Cancer
Researchers in the medical field have been studying cancer for quite some time. It is vital to note that niclosamide’s anticancer effects are most effective when used to the following malignancies.
Colon
- prostate
- breast
- osteosarcoma
- glioblastoma
- leukaemia
- ovarian
- lung
- cancer of the adrenocortex
Oral squamous cell carcinoma
Based on the available data, it seems that this medicine has the potential to damage a cancer cell’s mitochondria, stopping the cell’s development of tumours and triggering apoptosis.https://www.niclosam.com/shop/
